Lisa: Dad, just for once don't you want to try something new?
Homer: Oh Lisa, trying is just the first step toward failure.
Marge: Sitting that close to the TV is bad for your health.
Homer: Talking to me while I'm watching TV is bad for your health.
Homer: I hope I didn't brain my damage.
Homer: [after doing or saying something stupid] D'oh!
Homer: Well, I hope you've learnt your lesson, Lisa: never help anyone.
Bart: Dad, I can't believe you're risking my life to save your own.
Homer: Son, you'll understand one day, when you have kids.
Marge: Homer, it's easy to criticize. Homer: Fun, too.
[Lisa is strangling Bart] Homer: Lisa, no. Your hands are too weak. [begins strangling Bart]
Elf: Welcome to Santa's Village, where it's Christmas everyday! Closed on Christmas.
Agnes Skinner: You failed, Seymour. What is it with you and failure?
Homer: Marge, can I go out and play?
[catch-phrase] Mr. Burns: Excellent.
Homer: Take that, Lisa's beliefs!
Homer: Beer. Now there's a temporary solution.
Homer: Its been three days and my mind is clearer, my sperm count is up and I'm able to recognise simple shapes and patterns.
Lisa: Dad, you just said that three minutes ago.
Bart: Lisa made me do it. She cast a witch's spell on me.
Lisa: It's spelled Wicca, and it's empowering.
Bart: Wicca is just a Hollywood fad.
Lisa: That's Kabbala, jerk.
Chief Wiggum: [shopping for his wife at a women's clothing store] My wife's looking for something that doesn't make her look like a horse, so, I'm gonna be here for a while
Bart: Ay, carumba!
Homer: Kids, just because I don't care doesn't mean I'm not listening.
Principal Skinner: There's no justice like angry-mob justice.
Krusty the Clown: You, sir, are an idiot.
Mr. Burns: Whoa, slow down there maestro. There's a NEW Mexico?
Homer: Ahh, now to spend some quality time away from my family.
Moe: Oh boy, it looks like it's suicide again for me.
Marge: You should probably see a doctor about this...
Homer: OK. Marge: [realizing] A competent doctor. Homer: D'oh!
Agnes Skinner: 'Nuff talk, it's smashin' time.
Ned Flanders: You know, a man came into the store today and asked for change for a dollar, and I accidentally gave him three quarters. Took me all afternoon just to track him down.
Bart: [slapping Lisa] Don't hit Maggie. She's just a baby.
Homer: [slapping Bart] Don't hit Lisa. She's a girl.
Grampa: [slapping Homer] Keep your hands off of him Homer!
Mr. Burns: Smithers, release the hounds.
Homer: [Comforting] There, there. Shut up boy.
Homer: Oh, I'm in no condition to drive. Wait a minute. I don't have to listen to myself. I'm drunk.
Marge: Our differences are only skin deep, but our sames go down to the bone.
Homer: Boy, everyone is stupid except me.
Nelson: I feel like such a tool.
Marge: There's no shame in being a pariah.
Bart: Eat my shorts.
Bart: Don't have a cow, man.
Homer: I see the light... it burns!
Barney: I think we'd be all better off if each country had its own planet.
Homer: [to Marge] I toil not on ye Sabbath, Woman. A pox on thee!
Homer: Hey, Weener Boy... where do you think you'e going?
Quotes Source: IMDB